Status of combination drugs with betamethasone dipropionate and salicylic acid in the treatment of skin diseases
نویسندگان
چکیده
Topical glucocorticoids (GCs) have been used in dermatology for 60 years. The first GC applied topically was hydrocortisone, which was introduced into therapy by Sulzberger and Witten in 1952 [1]. Numerous studies undertaken in subsequent years, e.g. with a view to modifying the hydrocortisone molecule and developing advanced types of drug delivery vehicles, made it possible to enhance the anti-inflammatory and immunosuppressive properties, and improve the safety profile, of glucocorticoids [2]. Despite such a long history of therapeutic use, GCs continue to be used due to their anti-inflammatory, antiproliferative and immunosuppressive effects. The GCs are drugs of choice in a number of skin diseases including inflammatory, hyperproliferative and autoimmune dermatoses. The therapeutic effect of GCs depends on correct diagnosis, cooperation between the patient and the physician, potency of the drug, type of vehicle and application – as well as a range of genetic factors determining individual sensitivity [3]. In order to achieve better therapeutic effects, glucocorticoids are often combined with other substances such as salicylic acid. The latter has keratolytic properties and enhances GC penetration into the skin, which is of key importance for the treatment of excessively keratinized skin lesions [4].
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